Neonatal pharmacology and clinical implications

Abstract

In the neonatal period it is observed a physiological immaturity of organs and metabolic systems that influence the pharmacokinetics

and pharmacodynamics of administered drugs, whose dosage should be constantly amended, taking into consideration the progressive

increase in weight and the maturation of the metabolic pathways. A crucial objective in the pharmacological field is to define the

correct pharmacological dose. Drug underdosage may result in a loss of efficacy, whereas an overdosage can cause toxicity. The

rapid physiological changes in the neonatal period affect the safety and efficacy of the drug due to the various pharmacokinetic

phases (absorption, distribution, metabolism and excretion), therefore the infant cannot be considered as a “small adult”. In the

newborn, the volume of distribution of hydrophilic drugs is greater with respect to adults: this is due to the presence of a greater

relative volume of extracellular fluids and total body water, as well as to the lower relative amount of adipose tissue and muscular

mass. In general, it is known that the drugs excretion mechanisms are reduced in all infants. However these processes cannot be

generalized and the metabolism of each drug must be analysed on a case-by-case basis. The investigation and understanding of

the pharmacological processes of the neonatal organism to the administered drugs is extremely useful to determine the correct

dosage. However, many of the drugs for neonatal use remain poorly studied, and their dosage is often based on informations that

are extrapolated from the use in adults or in older children, because conducting clinical trials during the neonatal period is limited

for ethical and logistical reasons. In conclusion, the paediatric and adult population show significant differences with regard to the

absorption, distribution, metabolism and excretion of different drugs. The understanding of the differences with respect to adulthood

is fundamental to determine the correct dosage of drugs, in order to achieve the desired therapeutic effects and limit the toxic effects.

Author(s): Antonio Ruggiero

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